GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs10935120 | 1 | rs28409322 | chr3:134252385 | CEP63 | chr3:134204575-134293852:+ | -0.24 | -4.09 | 5.33E-5 | Height |
| BLCA | cis | rs732528 | 1 | rs2847577 | chr18:48364819 | MRO | chr18:48321491-48351754:- | -0.24 | -4.52 | 8.15E-6 | Entorhinal cortical thickness |
| BLCA | cis | rs732528 | 1 | rs2849246 | chr18:48371896 | MRO | chr18:48321491-48351754:- | -0.25 | -4.59 | 6.06E-6 | Entorhinal cortical thickness |
| BLCA | cis | rs9371538 | 1 | rs28517362 | chr6:151876387 | C6orf97 | chr6:151815175-151942327:+ | 0.28 | 4.1 | 5.13E-5 | Bone mineral density (spine) |
| BLCA | cis | rs6951245 | 1 | rs28528096 | chr7:1070912 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.31 | 2.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs1392635 | 1 | rs28546632 | chr15:69399728 | CALML4 | chr15:68483044-68498448:- | 0.24 | 3.87 | 0.00013 | Lipoprotein-associated phospholipase A2 activity change in response to statin therapy |
| BLCA | cis | rs4237643 | 1 | rs2862961 | chr11:43656535 | HSD17B12 | chr11:43702143-43878160:+ | 0.43 | 7.22 | 2.91E-12 | Forced vital capacity |
| BLCA | cis | rs4237643 | 1 | rs2862963 | chr11:43640115 | HSD17B12 | chr11:43702143-43878160:+ | 0.43 | 7.19 | 3.49E-12 | Forced vital capacity |
| BLCA | cis | rs4237643 | 1 | rs2862996 | chr11:43653833 | HSD17B12 | chr11:43702143-43878160:+ | -0.43 | -7.17 | 3.77E-12 | Forced vital capacity |
| BLCA | cis | rs344081 | 1 | rs28661978 | chr3:156579739 | LEKR1 | chr3:156544076-156763918:+ | -0.47 | -6.39 | 4.95E-10 | Bone mineral density |
| BLCA | cis | rs9902453 | 1 | rs28664971 | chr17:28437410 | EFCAB5 | chr17:28256874-28435469:+ | 0.23 | 3.93 | 0.000102 | Coffee consumption (cups per day) |
| BLCA | cis | rs7980687 | 1 | rs28683528 | chr12:123845351 | CDK2AP1 | chr12:123745542-123756687:- | -0.35 | -4.93 | 1.24E-6 | Educational attainment;Height;Head circumference (infant) |
| BLCA | cis | rs9815354 | 1 | rs28702390 | chr3:41889920 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.5 | 2.29E-19 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs28733681 | chr3:41863444 | ULK4 | chr3:41288091-42003660:- | 0.62 | 9.63 | 8.26E-20 | Diastolic blood pressure |
| BLCA | cis | rs344081 | 1 | rs2874490 | chr3:156635513 | LEKR1 | chr3:156544076-156763918:+ | -0.46 | -6.45 | 3.41E-10 | Bone mineral density |